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The Brain & the Actions of Cocaine Opiates and Marijuana

Enrolled: 1 student
Lectures: 25

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Learn how 3 drugs of abuse (cocaine, opiates, marijuana) actually work in the brain. The first section introduces the brain and presents some basic neurobiology, the second introduces the reward pathway and the third presents the mechanism of action of each drug and how each affects the reward system.

Introduction to the Brain

1
Introduction
2
Brain regions and neuronal pathways
3
Neuronal structure
4
The synapse and synaptic neurotransmission
5
Dopamine neurotransmission
6
Dopamine and the production of cyclic AMP
7
Summary of neuronal transmission

Introduction to the Reward System

1
Reward: drug self-administration
2
The reward pathway
3
Injection of cocaine into the nucleus accumbens

Introduction to Drugs of Abuse: Cocaine Opiates and Marijuana

1
Localization of cocaine binding sites
2
Dopamine binding to receptors and uptake pumps in the nucleus accumbens
3
Cocaine binding to uptake pumps: inhibition of dopamine uptake
4
Increased cAMP produced in post-synaptic cell
5
Summary – cocaine binding in nucleus accumbens and activation of reward pathway
6
Positron emission tomography (PET) scan of a person on cocaine
7
Localization of opioid binding sites
8
Opioids binding to opioid receptors in the nucleus accumbens: increased dopamine release
9
Increased cAMP produced in post-synaptic cell
10
Summary – opioid binding in nucleus accumbens and activation of the reward pathway
11
Localization of THC binding sites
12
THC binding to THC receptors in the nucleus accumbens: increased dopamine release
13
Increased cAMP produced in post-synaptic cell
14
Summary – THC binding in nucleus accumbens and activation of the reward pathway
15
Overall summary – these drugs of abuse all activate the reward system via increasing dopamine neurotransmission
We offer courses created by the worlds leading experts in addiction recovery. Our curriculum has been developed by top scientists who have spent their careers as addiction recovery professionals, addiction counselors or addiction researchers at the NIDA, SAMHSA and NIAAA.

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